Size

12 - 16 um in diameter

Cytoplasm

More abundant cytoplasm than small lymphocyte

Cytoplasm is weakly basophilic and stains pale blue

Have a dozen or so quite prominent azurophilic granules which contain lysosomal enzymes. These are called large granular lymphocytes, which are lymphokine-activated T cells and natural killer cells.

Nucleus

Round or slightly indented

Chromatin

Less condensed

Outline

Irregular